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Breed-specific DNA analysis
Breed-specific DNA analysis
Common genetic testing for the SBT
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Symptoms of L2HGA in different cases
L2HGA is a severe neurometabolic pathology that occurs when both dogs' parents are carriers and the dog has inherited two copies of the gene. The symptoms of L2HGA can be very varied and include seizures, spasms, ataxia, and abnormal changes in behavior, including stereotypies and compulsive behavior. Affected dogs tend to lose body control at least partly in time. Besides severe symptoms, which significantly affect a dog’s life quality, the tragic part of the disease is the fact that it’s not curable. Fortunately, today even carriers of this disease among Staffordshire bull terriers are quite rare to find: the breed community has done an excellent job removing carriers from the breeding. However, this does not mean that testing for L2HGA is not needed anymore - on the contrary, it is absolutely essential not to let it appear more often again. Carriers of L2HGA are commonly found precisely in those lines where testing has been neglected for several generations in a row.
L-2-HGA ( L- 2 - hydroxyglutaric aciduria ) L2HGA Laboklin testing https://www.laboklin.co.uk/laboklin/showGeneticTest.jsp?testID=8125
Hereditary cataracts (HC)
Hereditary cataracts (HC) affect the eyes of a dog, and over time lead to vision degradation. Unfortunately, the potential for their treatment is unfortunately quite limited. HC is a fairly common pathology among many various breeds, and some carriers can be found among the Staffordshire bull terrier too. And just like in the case with L2HGA, the fact that HC is not so common in SBT anymore, it shouldn't be a responsible reason to stop DNA testing. Otherwise, we could get much more of it very soon in upcoming generations. HC is not the only eye problem common in the breed, so it is highly recommended to complete an in-depth screening for other ophthalmological changes. More on eye screening HERE
Please note that not all DNA tests for HC determine it in Staffordshire bull terriers particularly. The selected test must detect SBT-type of HC.
Hereditary cataract (HSF4)* Laboklin testing
https://laboklin.com/en/products/genetics/hereditary-diseases/dog/hereditary-cataract-hsf4-2/
Please note that not all DNA tests for HC determine it in Staffordshire bull terriers particularly. The selected test must detect SBT-type of HC.
Hereditary cataract (HSF4)* Laboklin testing
https://laboklin.com/en/products/genetics/hereditary-diseases/dog/hereditary-cataract-hsf4-2/
- Clinical features and disease progression of L-2-hydroxyglutaric aciduria in 27 Staffordshire bull terriers. PMID: 27729589 DOI: 10.1136/vr.103783
- l‐2‐hydroxyglutaric aciduria: characterisation of the molecular defect in a spontaneous canine model. J Med Genet. 2007 May; 44(5): 334–340. doi: 10.1136/jmg.2006.042507
- Identifying Mutations Associated with HC in the Dog. Tufts' Canine and Feline Breeding and Genetics Conference, 2009
- Hereditary Cataracts. World Small Animal Veterinary Association World Congress Proceedings, 2006 Ellen Bjerkls, DVM PhD, DECVO
- Staffordshire Bull Terriers in the UK: their disorder predispositions and protections. DOI:10.1186/s40575-020-00092-w
References
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More about Staffordshire bull terrier
Is SBT the right match for you?
Despite all our love for SBT, we have to admit all breeds have their cons - it’s not avoidable. It remains to make sure that none of these cons are a red flag for your family and that you and your dog will become the right match.
Character of SBT
Each dog is an individual with its character and features, but breed representatives share many traits in common.
Showing and breeding dogs was never a main goal for me. I started in the dog world from behavioral modification and training, gained a degree in rehab and myotherapy, studied nutrition (raw/dry), trained nosework disciplines and already for several years owned an educational dog-blog and taught lectures for dog owners and professionals. Throughout all these fields I strongly promote complete/holistic approach and advocate for dog’s physical and mental wellbeing.
Showing and breeding dogs was never a main goal for me. I started in the dog world from behavioral modification and training, gained a degree in rehab and myotherapy, studied nutrition (raw/dry), trained nosework disciplines and already for several years owned an educational dog-blog and taught lectures for dog owners and professionals. Throughout all these fields I strongly promote complete/holistic approach and advocate for dog’s physical and mental wellbeing.
Showing and breeding dogs was never a main goal for me. I started in the dog world from behavioral modification and training, gained a degree in rehab and myotherapy, studied nutrition (raw/dry), trained nosework disciplines and already for several years owned an educational dog-blog and taught lectures for dog owners and professionals. Throughout all these fields I strongly promote complete/holistic approach and advocate for dog’s physical and mental wellbeing.
